Entwodiksyon: Dapre Òganizasyon Mondyal Lasante, plis pase 2 milyon fanm atravè lemond yo dyagnostike ak kansè nan tete chak ane. Se kansè ki pi komen nan fanm nan mond lan, li touye prèske 700,000 moun chak ane.
Apeprè 40 pousan nan moun yo dyagnostike ak maladi a fini gen sibi mastèktomi, ki enplike nan retire pasyèl oswa konplè nan tisi tete ki afekte a. Sepandan, ak tretman modèn, to sivivan se plis pase 90 pousan, ki vle di ke pi plis ak plis fanm ap chèche tretman rekonstriksyon tete pou ranplase tisi ki pèdi.
△Bioprinted breast implants contain patient cells to improve transplant success, image via Healshape
French Healshape resevwa 6.8 milyon dola nan Seri A finansman
23 janvye 2022, Antarctic Bear te aprann ke Healshape, yon demaraj medikaman rejeneratif franse, te ogmante 6.8 milyon dola (apeprè 43 milyon dola Yuan) nan Seri A finansman pou devlope implants tete bioprinted 3D lè l sèvi avèk selil pasyan vivan.
Konpayi an, ki te sipòte pa akseleratè transfè teknoloji Pulsalys SAS, te resevwa plis pase 1 milyon nan fon pro bono ak sibvansyon nan men Lafrans depi lansman li an janvye 2020.
Healshape's mission is to provide specific 3D bioprinted breast prostheses for breast cancer patients undergoing mastectomy. These implants can be printed in virtually any shape and size and can help rebuild breasts and nipples without the risk of implant rejection.
Sophie Brac de la Perrière, CEO of Healshape, said: "Female patients will have their breasts restored within 6 to 9 months, with no trace of a bioprosthesis. This will help patients accept their own image and recreate their own body. Satisfied."
△Healshape scientists 3D bioprinted custom breast implants, photo from Healshape
Précédemment, operasyon rekonstriksyon tete yo te itilize tipikman enplantasyon atifisyèl, oswa matris tisi mou soti nan lòt moun ak bèt. Enplantasyon ki soti nan sous sa yo toujou nan risk pou yo gen yon reyaksyon iminitè ki ka retade pwosesis gerizon an.
Healshape's tissue engineering approach addresses these issues by combining 3D bioprinting technology with live cell cultures taken from the patient's own body.
Bioprinted implants tete absorbable
Healshape's bioprosthetic technology relies on an absorbable hydrogel that can be 3D bioprinted into any freeform shape. Once implanted in the human body, fat transfer from the patient's own body cells facilitates the colonization of the breast implant and allows it to develop into natural breast tissue, while all of this hydrogel is gradually absorbed and replaced.
Healshape's technology is the result of a bioprinting study in collaboration with a research group led by Christophe Marquette, a senior researcher at the Institute for Molecular and Supramolecular Research at the French National Centre for Scientific Research (ICBMS). Marquette also leads the 3d.FAB platform and founded the tissue engineering company LabSkin Creations. Healshape's bioink technology is currently patent protected.
Marquette added: "Originally, the technology was developed for printing skin substitutes. For the Healshape project, it was necessary to adapt the process to print volumes and ensure subsequent consolidation of the bioink to make it compatible for implantation in vivo" .
Healshape's 3D bioprinting technology is currently in the preclinical stage, with clinical trials expected to begin within the next two years.
Pwogrè rechèch nan pwotèz tete mondyal enprime 3D
Nan 2016, Zhang Xue (pseudonim), ki te soufri kansè nan tete, te trete nan Lopital Xijing. Nan tan sa a, gwosè timè a te depase 6 cm, e malgre chimyoterapi neoadjuvant, sèlman yon mastèktomi total te fèt. Ekspè yo te deside fè operasyon rekonstriksyon tete ak òdinatè-enpresyon 4D materyèl biodégradables.
Anvan operasyon an, ekip ki soti nan Depatman Radyoloji, Lopital Xijing te fè yon eskanè MRI tete mens -. Ekip chirijikal la te kolekte avèk presizyon timè ak enfòmasyon imaj tete atravè MRI, epi li te fè rekonstriksyon 3D ak simulation reseksyon sou òdinatè a. Sou baz sa a, gwosè filler la fèt jisteman dapre defo tisi a simulation, epi sit defo a enprime 3D youn-a-yon sèl.
△ 4D printed biodegradable material filler
Nan jou operasyon an, direktè Ling Rui ak pwofesè asosye Zhang Juliang nan Depatman Operasyon vaskilè tete nan Lopital Xijing te fè eksizyon vaste nan kansè nan tete gòch ak diseksyon ne lenfatik axilè ki baze sou rezilta yo nan simulation òdinatè. Pre-enjenyè 4D-materyèl biodégradables ki enprime ranpli pou rekonstriksyon tete siksè. Pasyan an refè byen apre operasyon an epi yo te egzeyate sou twazyèm jou a. Pasyan an te resevwa tou radyoterapi regilyèman apre operasyon an. Apre plizyè re-egzamen, enplantasyon yo te fòme piti piti, e yo te gen bon konpatibilite tisi, ak tisi fibrovasculaire otològ yo te kòmanse grandi.
An 2018, de etidyan University of Plymouth Rosie Brave ak Sam Jackman te kreye yon fo tete woz ki te enprime 3D-ki pral chanje lavi moun ki sivivan kansè nan tete yo.
Brave was inspired by Jackman's mother, who had had surgery and had traditional breast implants installed, but was confused by the "sweaty" and "uncomfortable" breast implants.
Se konsa, Brave ak Jackman te kòmanse repanse konplètman konsepsyon implant tete epi vini ak desen ki ta pote lajwa nan moun ki mete yo. Modèl yo enprime 3D yo kreye yo kolore, limyè ak rèspirant, epi yo fèt ak moun ki te fè eksperyans chòk nan kansè nan tete ak mastèktomi.
An 2019, New Zeland-demaraj medikal-up myReflection te itilize analiz 3D ak mwazi enprime 3D pou devlope enplantasyon tete pèsonalize pou pasyan kansè apre mastèktomi.
Pwotèz la sèvi ak teknoloji eskanè 3D pou detèmine dimansyon ekstèn yo, epi li fèt ak yon nwayo enteryè ak yon materyèl silikon ki sètifye ISO-sou deyò.
△Customized breast prosthesis made with 3D printing mold, picture from myReflection
An 2021, Kore di Sid-demaraj biotech Plcoskin te anonse ke li ta mennen yon pwojè rechèch entènasyonal ansanm ki konsantre sou devlope yon nouvo kalite enplantasyon tete enprime 3D. Ansanm ak Yonsei University ak LipoCoat, yon konpayi kouvwi aparèy medikal ki baze nan Netherlands-, Plcoskin pral resevwa anviwon 2 milya won (1.7 milyon) nan finansman pandan twa pwochen ane yo.
An 2021, manifakti enprimant 3D 3D Systems dènyèman te anonse yon akò ko-devlopman ak konpayi medikaman rejeneratif CollPlant pou devlope estrikti tisi mou 3D bioprinted pou tretman rekonstriksyon tete. Yo pral itilize estrikti tisi mou pou bay sipò nan pati ki pi ba nan tete a epi ogmante pwoteksyon an jeneral nan implant la. Menm jan ak Healshape, objektif final la se amelyore siksè operasyon rekonstriksyon tete pou sivivan kansè yo.
